We adopted a robust rank aggregation score system to systematically measure the impact power of gene perturbation on T cells from various dataset level,
TPS = 0.2 * -lg(RobustRankAgg rho)
The measurement of TPS-score was in a range of 0 - 1.
Genes with large TPS-scroe indicates the high expression of which may contribute to enhancing T cell functions therapy, while genes with small TPS-score associate with less impacts on T cell functions.
The TPS-scores provides researchers the degree of overall genes impacting on shaping T cell functionalities.
Copyright © Chen Lab, Yale School of Medicine, New Haven, CT 06516
Any comments and dataset suggestions, please contact us AT chuanpeng.dong@yale.edu